AAV Gene Therapy Manufacturing for Non-Scientists

  • Course Price: $150 USD
  • BIO Member Price: 120
  • Course Run Time: 56 minutes
  • Course Level: Level 2 - General
  • Completion Period: 2 week

AAV Gene Therapy Manufacturing explains the features and functions of AAV viral vector platforms, focusing on Triple Transient Transfection. An explanation of the upstream bioprocessing, cell harvesting, downstream bioprocessing, fill and finish, and packaging of AAV gene therapy products is given. The class ends with a review of the CMC regulatory component of AAV manufacturing.

Suggested Prerequisites

The Biology of Biotech
Introduction to Genetic Engineering
Biomanufacturing

Takeaways
  1. Fluency in the structures and functions of AAV.
  2. Knowledge of how AAV serotypes influence tissue tropism.
  3. Compare and contrast the four primary AAV vector platforms.
  4. Understanding the manufacturing workflow's purpose: upstream bioprocessing, cell harvesting, downstream bioprocessing, fill and finish, and packaging.
  5. Survey of the key guidances for CMC testing of AAV viral vectors.
Certificate Requirements
  • View the entire course
  • Pass course exam with a 70 percen
Download Agenda
Certificate Requirements
  • View the entire course
  • Pass course exam with a 70 percen
Trailer
Section 1: AAV Properties
Section 2: AAV Production Platforms
Section 3: AAV Upstream Bioprocessing
Section 4: AAV Downstream Bioprocessing
Section 5: AAV CMC
Final Quiz
Certificate Requirements
  • View the entire course
  • Pass course exam with a 70 percen